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Altering the E. coli Ribosome Exit Tunnel to Improve Consecutive Incorporation of Challenging Monomers (ACS Cent Sci, 2026)

NSF C-GEM researchers and collaborators found that mutating the exit tunnel of the ribosome allows it to accommodate larger monomers that previously would have gotten stuck, stalling the translation process.  Read more about the paper on the NSF C-GEM blog, where co-first author Dr. Chandrima… Read More »Altering the E. coli Ribosome Exit Tunnel to Improve Consecutive Incorporation of Challenging Monomers (ACS Cent Sci, 2026)

Repurposing Engineered Aminoacyl-tRNA Synthetases for Proximity-Dependent Protein Labeling through the Release of Aminoacyl-AMP Intermediate (ACS Chem Biol, 2026)

NSF C-GEM researchers and collaborators found a novel pathway for protein labeling using engineered aminoacyl-tRNA Synthetases (aaRS) and non-canonical amino acids (ncAAs). In the absence of their cognate tRNAs, engineered aaRSs can release reactive ncAA-AMP intermediates that covalently label nearby proteins. This system for proximity-dependent… Read More »Repurposing Engineered Aminoacyl-tRNA Synthetases for Proximity-Dependent Protein Labeling through the Release of Aminoacyl-AMP Intermediate (ACS Chem Biol, 2026)

Thomas Li presents at Quantum-Si seminar

This week, Thomas Li (graduate student, UC Berkeley) presented his research at Quantum-Si’s “Precision Proteomics: Sequencing Proteins with Single-Molecule Resolution” seminar at UC Berkeley. Congratulations to Thomas for his presentation!

NSF C-GEM brings polymer science to Bay Area elementary schoolers

On Tuesday, C-GEM researchers—Vincent Chim (graduate student, UC Berkeley), Helena Roberts-Mataric (graduate student, UC Berkeley), Izzi Piper (graduate student, UC Berkeley), and Qi Xie (postdoc, UC Berkeley)—participated in Community Resources for Science’s (CRS) Bay Area Scientists Inspiring Students (BASIS) program. C-GEM partnered with CRS to… Read More »NSF C-GEM brings polymer science to Bay Area elementary schoolers

Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome (J Am Chem Soc, 2026)

By Alexandra Kent The goal of C-GEM is to generate ribosomally synthesized, sequence-defined polymers using a diverse set of non-natural monomers. Although ribosomes are known to incorporate some unnatural monomers, the basis for observed differences in incorporation efficiencies of different stereoisomers remains poorly understood. In… Read More »Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome (J Am Chem Soc, 2026)