Publications

2022

Walker, J. A.; Hamlish, N.; Tytla, A.; Brauer, D. D.; Francis, M. B.; Schepartz, A. Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates. ACS Central Science 2022, https://doi.org/10.1021/acscentsci.1c01577

Fricke, R.*; Swenson, C.*; Roe, L. T.; Hamlish, N.; Ad, O.; Smaga, S.; Gee, C. L.; Schepartz, A. Orthogonal Synthetases for Polyketide Precursors. bioRxiv 2022, https://doi.org/10.1101/2022.02.28.482149.

Radford, F.; Elliott, S. D.; Schepartz, A.; Isaacs, F. J. Targeted Editing and Evolution of Engineered Ribosomes in Vivo by Filtered EditingNat Commun 202213 (1), 180. https://doi.org/10.1038/s41467-021-27836-x.

2021

Santiago, S.; Ad, O.; Shah, B.; Zhang, Z.; Zhang, X.; Chatterjee, A.; Schepartz, A. Genetic Code Expansion in the Engineered Organism Vmax X2: High Yield and Exceptional Fidelity; ACS Central Science 2021. https://doi.org/10.1021/acscentsci.1c00499.

Gaffney, S. G.; Smaga, S.; Schepartz, A.; Townsend, J. P. Chemsearch: Collaborative Compound Libraries with Structure-Aware BrowsingBioinformatics Advances 2021, vbab008. https://doi.org/10.1093/bioadv/vbab008.

Tharp, J. M.*; Walker, J. A.*; Söll, D.; Schepartz, A. Initiating Protein Synthesis with Noncanonical Monomers in Vitro and in Vivo. In Methods in Enzymology; Academic Press, 2021. https://doi.org/10.1016/bs.mie.2021.05.002.

Tharp, J. M.; Vargas-Rodriguez, O.; Schepartz, A.; Söll, D. Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense CodonsACS Chem Biol 202116 (4), 766–774. https://doi.org/10.1021/acschembio.1c00120.

2020

Krahn, N.; Tharp, J. M.; Crnković, A.; Söll, D. Engineering Aminoacyl-TRNA Synthetases for Use in Synthetic Biology. In The Enzymes; Academic Press, 2020. doi:10.1016/bs.enz.2020.06.004.

Watson, Z. L.; Ward, F. R.; Méheust, R.; Ad, O.; Schepartz, A.; Banfield, J. F.; Cate, J. H. D., Structure of the Bacterial Ribosome at 2 Å Resolution. eLife 2020. doi:10.7554/eLife.60482.
Data: PDB (7K00) | EMDR (22586)

Walker, A. S.; Russ, W. P.; Ranganathan, R.; Schepartz, A. RNA Sectors and Allosteric Function within the RibosomePNAS 2020. 117 (33). 19879-19887.

Tharp, J. M.; Krahn, N.; Varshney, U.; Söll, D., Hijacking translation initiation for synthetic biology, ChemBioChem 2020, 21 (10). 1387-1396.

Tharp, J. M.; Ad, O.; Amikura, K.; Ward, F. R.; Garcia, E. M.; Cate, J. H. D.; Schepartz, A.; Söll, D., Initiation of protein synthesis with non-canonical amino acids in vivo, Angew Chem Int Ed 2020, 59 (8). 3122-3126.

2019

Ward, F. R.*; Watson, Z. L.*; Ad, O.; Schepartz, A.; Cate, J. H. D., Defects in the assembly of ribosomes selected for β-amino acid incorporation, Biochemistry 2019, 58, 4494-4504.
Data: WT 50S (EMD 20853) | P7A7 50S (EMD 20854)

Ad, O.; Hoffman, K. S.; Cairns, A. G.; Featherston, A. L.; Miller, S. J.; Söll, D.; Schepartz, A., Translation of diverse aramid- and 1,3-dicarbonyl-peptides by wild type ribosomes in vitro, ACS Cent Sci 2019, 5, 1289–1294.

Gaffney, S. G.; Ad, O.; Smaga, S.; Schepartz, A.; Townsend, J. P., GEM-NET: Lessons in multi-institution teamwork using collaboration software, ACS Cent Sci 2019, 5, 1159–1169.

2018

Hoffman, K. S.; Crnković, A.; Söll, D., Versatility of synthetic tRNAs in genetic code expansion, Genes 2018, 9, epub.

Vargas-Rodriguez, O.; Sevostyanova, A.; Söll, D.; Crnković, A., Upgrading aminoacyl-tRNA synthetases for genetic code expansion, Curr Opin Chem Biol 2018, 46, 115-122. 

Arranz-Gibert, P.; Vanderschuren, K.; Isaacs, F. J., Next-generation genetic code expansion, Curr Opin Chem Biol 2018, 46, 203-211.

Barber, K. W.; Muir, P.; Szeligowski, R. V.; Rogulina, S.; Gerstein, M.; Sampson, J. R.; Isaacs, F. J.;
Rinehart, J., Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions, Nat Biotechnol 2018, 36, 638-644.

Schepartz, A., Foldamers wave to the ribosome, Nat Chem 2018, 10, 377.

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