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2021

Rhiju Das and Dave Savage named HHMI Investigators

Congratulations to C-GEM Senior Investigator Rhiju Das and C-GEM Seed Investigator Dave Savage for both being named Howard Hughes Medical Institute Investigators. HHMI Investigators are awarded $9 million over the course of seven years to do research to further the field of biomedical research.

New paper: Genetic code expansion with high yield and exceptional fidelity

Genetic code expansion has tremendous potential to revolutionize peptide, protein, and protein-like therapeutics through the strategic substitution of non-canonical amino acids – or even more exotic monomers – to improve functional diversity, pharmacodynamics, produce antibody-drug conjugates, or even generate novel macrocycles. In all of these… Read More »New paper: Genetic code expansion with high yield and exceptional fidelity

Ribosomes: A vision of the future utilizing antibiotic-ribosome relationships

Alexis Vanzandt (left) and Kaitlyn Szalay (right) are undergraduate students who participated in the C-GEM summer research program. Their project focused on analyzing and integrating antibiotic-ribosome mutation data to aid in the accessibility of ribosome information and propel future studies. During the Center for Genetically… Read More »Ribosomes: A vision of the future utilizing antibiotic-ribosome relationships

The journey to creating unnatural polymers using the ribosome

Margaret Adenusi (left) and Alyssa Virola-Iarussi (right) are undergraduate students in the 2021 C-GEM summer research program, who are analyzing acylation data to identify structure-activity relationships that will enable efficient flexizyme-mediated tRNA misacylation with backbone-altered monomers. Presume a world where pharmaceutical drugs do not expire,… Read More »The journey to creating unnatural polymers using the ribosome