Cell-free protein synthesis (CFPS) is a powerful way to explore the synthesis of proteins and other polymers outside of the cellular environment
In our third podcast, Jeffrey Townsend interviews Rhiju Das, an Associate Professor of Biochemistry at Stanford University and our newest C-GEM member.
C-GEM scientists explain EvolvR technology.
A recent study by Ruben L. Gonzalez Jr. and coworkers provides insight into how to improve the incorporation of D-α-amino acids into proteins.
By Patrick Ginther In a recent 2018 Nature news & views, the work of Jason Chin and co-workers was highlighted for the lab’s extraordinary work on developing new tools for synthetic biology [1]. Specifically, Chin and co-workers successfully generated a variant of the pyrrolysyl-tRNA synthetase/tRNA… Read More »Driving orthogonality between variant pyrrolysyl-tRNA synthetase/tRNA pairs
In our second podcast, Jeffrey Townsend interviews Alanna Schepartz, the head of C-GEM.
In our first podcast, Ellen Kan, staff reporter at the Yale Daily News, interviews Jeffrey Townsend about the new Center for Genetically Encoded Materials. We cover what the Center is, what it will be doing, and what technologies it could lead to. This interview was… Read More »Ellen Kan of the Yale Daily News interviews Jeffrey Townsend
Riboswitches are defined as RNA structures, typically found in the 5’ untranslated region (5’UTR) of mRNA, that sense and respond to small molecules, metabolites, or coenzymes to regulate transcription and translation.
Ribosome assembly is a remarkably complex cellular process. In the yeast large subunit (60S) alone, it requires the ordered association and folding of 3 rRNAs and 46 r-proteins as the nascent ribosomes move from the nucleolus, to the nucleus, and finally to the cytoplasm.
In a recent paper in JACS, Schultz and co-workers present a strategy where replacing a key amino acid of an enzyme by a non-standard amino acid (nsAA) produces an organism that requires this nsAA for survival. ..