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Sarah Smaga

New paper: Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates

Led by C-GEM postdoc Josh Walker, this paper describes the installation of thiazoline and thiazole backbone modifications in peptides and proteins, including those containing non-natural monomers. This work is a collaboration between the Schepartz and Francis labs, with contributions from Noah Hamlish, Avery Tytla, and… Read More »New paper: Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates

New paper: genetic code expansion with high yield and exceptional fidelity

Genetic code expansion has tremendous potential to revolutionize peptide, protein, and protein-like therapeutics through the strategic substitution of non-canonical amino acids – or even more exotic monomers – to improve functional diversity, pharmacodynamics, produce antibody-drug conjugates, or even generate novel macrocycles. In all of these… Read More »New paper: genetic code expansion with high yield and exceptional fidelity

Congrats, C-GEM Graduates!

A warm congratulations to Fred Ward and Zoe Watson who completed their PhDs in the Cate lab at UC Berkeley this past year. Check out some of their thesis work below:

Leah Roe named Hertz Finalist

Congratulations to Schepartz Lab graduate student Leah Roe for being named a finalist for the 2021 Hertz Foundation graduate fellowship! Leah completed her undergraduate degree in Molecular and Cellular Biology at UC Berkeley, then worked at UCSF before joining the UC Berkeley Chemistry PhD program.