Led by C-GEM postdoc Josh Walker, this paper describes the installation of thiazoline and thiazole backbone modifications in peptides and proteins, including those containing non-natural monomers. This work is a collaboration between the Schepartz and Francis labs, with contributions from Noah Hamlish, Avery Tytla, and Dan Brauer. Read the paper.
New paper: Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
- by Sarah Smaga