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Direct and quantitative analysis of tRNA acylation using intact tRNA liquid chromatography–mass spectrometry (Nat Protoc, 2025)

C-GEM researchers developed a fast, simple, and generalizable method to assay aminoacyl-tRNA synthetase activity by detecting the acylated tRNA product using liquid chromatography–mass spectrometry. C-GEM first developed this method as a way to identify aminoacyl-tRNA synthetase enzymes that accept non-α-amino acid substrates even at extremely… Read More »Direct and quantitative analysis of tRNA acylation using intact tRNA liquid chromatography–mass spectrometry (Nat Protoc, 2025)

A ribosome in front of a graphical representation of the GARNET database.

RNA language models predict mutations that improve RNA function (Nat Commun, 2024)

C-GEM published a new paper in Nature Communications in collaboration with the Innovative Genomics Institute. Our researchers developed an RNA language model to predict mutations that could lead to improved structural stability. This model was used to predict mutations that could lead to improved thermostability… Read More »RNA language models predict mutations that improve RNA function (Nat Commun, 2024)

SURP scholar wins travel award to ABRCMS 2024

Congratulations to C-GEM SURP alumna Anika Accomando for winning a travel award to attend ABRCMS! She presented a poster on the research she did over the summer in Senior Investigator Scott Miller’s lab, mentored by Taylor Dover (graduate student, Yale).

Arjun Garapaty wins a poster award at NDiSTEM

Congratulations to Arjun Garapaty (undergraduate, Schepartz lab) for being awarded a travel award to attend NDiSTEM this past weekend! Arjun did a great job presenting his poster and won a poster award for his work. Well deserved, Arjun!

Carly Schissel featured on the Drug Diaries podcast

Carly Schissel (postdoc, UC Berkeley) was featured on an episode of Drug Diaries. She talked about her pathway through academia, how she became interested in chemical biology, and her research as a C-GEM scientist. Listen and watch the episode here: