Skip to content

admin

Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome (J Am Chem Soc, 2026)

By Alexandra Kent The goal of C-GEM is to generate ribosomally synthesized, sequence-defined polymers using a diverse set of non-natural monomers. Although ribosomes are known to incorporate some unnatural monomers, the basis for observed differences in incorporation efficiencies of different stereoisomers remains poorly understood. In… Read More »Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome (J Am Chem Soc, 2026)

Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases (J Am Chem Soc, 2026)

By Chintan Soni Proteins are powerful and versatile molecules with immense potential in medicine and the materials industry, but they are built from just 20 natural α-amino acids, linked through an α- amide backbone, limiting the range diversity of structures and functions they can achieve.… Read More »Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases (J Am Chem Soc, 2026)

C-GEM Represents at 2026 Peptides GRC

Left: (left to right) Christopher Alabi (Senior Investigator, Cornell), Abhishek Chatterjee (Senior Investigator, Boston College), Alex Solivan (graduate student, UC Berkeley), Taylor Dover (graduate student, Yale), Meghna Bajaj (graduate student, Cornell), Carly Schissel (Assistant Professor, Penn State, former C-GEM postdoctoral scholar).Right: Meghna Bajaj holding her… Read More »C-GEM Represents at 2026 Peptides GRC

Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines (Nat Chem, 2025)

Most scientists have a complex love/hate relationship with peptides, especially in the field of drug discovery. Peptides are encodable, for sure, but they are also structurally featureless and often display exceptionally poor bioavailability and cell permeability. In this work, C-GEM researchers developed chemistry with the… Read More »Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines (Nat Chem, 2025)

Site-selective protein editing by backbone extension acyl rearrangements (Nat Chem Biol, 2025)

Researchers at the NSF Center for Genetically Encoded Materials (C-GEM) developed a novel and versatile chemo-ribosomal strategy to generate isolable quantities of protein-derived biopolymers containing site-specific backbone modifications. This strategy relies on an intramolecular backbone-extension acyl rearrangement (BEAR) reaction that post-translationally and site-specifically rearranges the… Read More »Site-selective protein editing by backbone extension acyl rearrangements (Nat Chem Biol, 2025)