In a recent paper in JACS, Schultz and co-workers present a strategy where replacing a key amino acid of an enzyme by a non-standard amino acid (nsAA) produces an organism that requires this nsAA for survival. ..
Posttranslational modifications (PTMs) are responsible for some of the most exotic ribosomally synthesized peptide backbones in biology.
the most recent issue of Organic and Biomolecular Chemistry, a paper from Matthew Hartman’s lab highlights the use of an editing-deficient valine-tRNA synthetase (ValRS T222P) to incorporate 11 non-canonical amino acids (ncAAs) into peptides synthesized in vitro.
An article about C-GEM appeared in Yale Daily News: New center to advance chemistry research.
An article about C-GEM appeared in Yale News: Grant will create Center for Genomically Encoded Materials at Yale.