Check out this Berkeley News article about how three recent papers from C-GEM advance our goal of repurposing the translational machinery to make new polymers. And read the papers 2. Expanding the Substrate Scope of Pyrrolysyl-Transfer RNA Synthetase Enzymes to Include Non-α-Amino Acids in Vitro… Read More »C-GEM research featured in Berkeley News!
Led by C-GEM graduate student Amos Nissley in the Cate Lab, this paper describes chimeric ribosomes that incorporate sequences from certain hyperthermophilic Archaea into the E. coli ribosome. These chimeric ribosomes showed higher thermotolerance than the E. coli ribosome with no change in structure. Additionally,… Read More »New paper: Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome
Led by C-GEM postdoc Josh Walker, this paper describes the installation of thiazoline and thiazole backbone modifications in peptides and proteins, including those containing non-natural monomers. This work is a collaboration between the Schepartz and Francis labs, with contributions from Noah Hamlish, Avery Tytla, and… Read More »New paper: Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
Genetic code expansion has tremendous potential to revolutionize peptide, protein, and protein-like therapeutics through the strategic substitution of non-canonical amino acids – or even more exotic monomers – to improve functional diversity, pharmacodynamics, produce antibody-drug conjugates, or even generate novel macrocycles. In all of these… Read More »New paper: genetic code expansion with high yield and exceptional fidelity