Publications

Led by C-GEM graduate student Amos Nissley in the Cate Lab, this paper describes chimeric ribosomes that incorporate sequences from certain hyperthermophilic Archaea into the E. coli ribosome. These chimeric ribosomes showed higher thermotolerance than the E. coli ribosome with no change in structure. Additionally,… Read More »New paper: Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome

Led by C-GEM postdoc Josh Walker, this paper describes the installation of thiazoline and thiazole backbone modifications in peptides and proteins, including those containing non-natural monomers. This work is a collaboration between the Schepartz and Francis labs, with contributions from Noah Hamlish, Avery Tytla, and… Read More »New paper: Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates

Genetic code expansion has tremendous potential to revolutionize peptide, protein, and protein-like therapeutics through the strategic substitution of non-canonical amino acids – or even more exotic monomers – to improve functional diversity, pharmacodynamics, produce antibody-drug conjugates, or even generate novel macrocycles. In all of these… Read More »New paper: genetic code expansion with high yield and exceptional fidelity