Scott Miller

Scott Miller

Investigator

Biography

Scott J. Miller was born on December 11, 1966 in Buffalo, NY. He received his B.A. (1989), M.A. (1989) and Ph.D. (1994) from Harvard University, where he worked with David Evans as a National Science Foundation Predoctoral Fellow. Subsequently, he traveled to the California Institute of Technology where he was a National Science Foundation Postdoctoral Fellow with Robert Grubbs until 1996. For the following decade, he was a member of the faculty at Boston College, until joining the faculty at Yale University in 2006. In 2008, he was appointed as the Irénée du Pont Professor of Chemistry.

Research interests

Professor Miller’s research program focuses on catalysis. His group employs strategies that include catalyst design, the development of techniques for catalyst screening, and the application of new catalysts to the preparation of biologically active agents. Four current interests are (a) the selective functionalization of complex molecules, (b) the exploration of analogies between synthetic catalysts and enzymes, (c) the discovery of effective antibiotics despite increasing resistance, and (d) the engineering of the biosynthetic apparatus for nonextant bond-formation.

Distinctions and Awards

Scott Miller’s awards and honors include: National Science Foundation CAREER Award (1999), Alfred P. Sloan Research Fellowship (2000), Camille Dreyfus Teacher-Scholar Award (2000), Arthur C. Cope Scholar Award of the American Chemical Society (2004), Yoshimasa Hirata Memorial Gold Medal of Nagoya University (2009), National Institutes of Health MERIT Award (2011), Fellow of the American Association for the Advancement of Science (2012), American Chemical Society Award for Creative Work in Synthetic Organic Chemistry (2016), Member, American Academy of Arts and Sciences (2016), Max Tishler Prize, Harvard University (2017), Fellow of the American Chemical Society (2018).

Recent publications

  • “Diversity of Secondary Structure in Catalytic Peptides with b-Turn-Biased Sequences”. Metrano, A. J.; Abascal, N. C.; Mercado, B. Q.; Paulson, E. K.; Hurtley, A. E.; Miller, S. J. J. Am. Chem. Soc. 2017, 139, 492-516.

  • “Site- and Stereoselective Chemical Editing of Thiostrepton by Rh-Catalyzed Conjugate Arylation: New Analogs and Collateral Enantioselective Synthesis of Amino Acids”. Key, H. M.; Miller, S. J. J. Am. Chem. Soc. 2017, 139, 15460-15466.

  • “Rapid Phenolic O-Glycosylation of Small Molecules and Complex Unprotected Peptides in Aqueous Solvent”. Wadzinski, T. J.; Steinauer, A.; Hie, L.; Pelletier, G.; Schepartz, A.; Miller, S. J. Nature Chem. 2018, 10, 644-652.

  • “Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C−N Bond-Forming Cross-Coupling and Catalyst-Controlled Atroposelective Cyclodehydration”. Kwon, Y.; Chinn, A. J.; Kim, B.; Miller, S. J. Angew. Chem. Int. Ed. 2018, 57, 6251-6255.

  • “A Stereodynamic Redox-Interconversion Network of Vicinal Tertiary and Quaternary Carbon Stereocenters in Hydroquinone-Quinone Hybrid Dihydrobenzofurans”. Storch, G.; Kim, B.; Mercado, B. Q.; Miller, S. J. Angew. Chem. Int. Ed. 2018, 57, 15107-15111.

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